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Article

De novo infection and propagation of wild-type Hepatitis C virus in human T lymphocytes in vitro

10 Nov 2006

Abstract excerpt

While exploring previous findings that ex vivo treatment of lymphoid cells from Hepatitis C virus (HCV)-infected individuals with T cell-stimulating mitogens augments detection of the residing virus, an in vitro HCV replication system was established, in which mitogen-induced T cell-enriched cultures served as HCV targets and the derived T cells multiplied virus during repeated serial passage. HCV replication was...

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PMID: 17098973
DOI: 10.1099/vir.0.81868-0

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