Article
Characterization of in vitro biofilm-associated pneumococcal phase variants of a clinically relevant serotype 3 clone.
Journal of clinical microbiology - 1 Jan 2007
McEllistrem M Catherine, Ransford Jennifer V, Khan Saleem A
Abstract excerpt
An increasing proportion of children with acute otitis media due to Streptococcus pneumoniae have serotype 3 infections since licensure of the seven-valent pneumococcal conjugate vaccine. These serotype 3 strains are genetically related by molecular subtyping. During otitis media with effusion and recurrent otitis media, biofilms commonly develop. Pneumococcal in vitro biofilms are comprised of phase variants...
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