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Article

The mechanism of gene targeting in Physcomitrella patens: homologous recombination, concatenation and multiple integration.

Nucleic acids research - 1 Jan 2006

Kamisugi Yasuko, Schlink Katja, Rensing Stefan A, Schween Gabriele, von Stackelberg Mark, Cuming Andrew C, Reski Ralf, Cove David J

Abstract excerpt

The model bryophyte Physcomitrella patens exhibits high frequencies of gene targeting when transformed with DNA constructs containing sequences homologous with genomic loci. 'Targeted gene replacement' (TGR) resulting from homologous recombination (HR) between each end of a targeting construct an...

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Identifiers

PMID: 17090599
DOI: 10.1093/nar/gkl832
PMCID: PMC1693892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17090599-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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