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Article

Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications.

Circulation - 14 Nov 2006

Tan Hanno L, Bardai Abdennasser, Shimizu Wataru, Moss Arthur J, Schulze-Bahr Eric, Noda Takashi, Wilde Arthur A M

Abstract excerpt

BACKGROUND: The identification of the molecular-genetic substrate underlying the various forms of the congenital long-QT syndrome (LQTS) has sparked studies into possible genotype-phenotype correlations with the aim of developing genotype-tailored therapy. The onset of torsade de pointes (TdP) may differ among LQTS patients, being pause dependent in some but not all. This disparity may point to different...

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Identifiers

PMID: 17088455
DOI: 10.1161/CIRCULATIONAHA.106.642694

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