Loss of rapid transferrin receptor recycling due to a mutation in Sec15l1 in hbd mice.

Abstract excerpt

The hbd (hemoglobin deficit) mutation affects iron trafficking in murine reticulocytes. It is due to a deletion that eliminates exon 8 of Sec15l1, the homolog of a gene that encodes an exocyst component in yeast. We tested the hypothesis that the mutation causes defective slow or rapid receptor recycling by measuring endocytosis and exocytosis of transferrin by hbd reticulocytes. Endocytosis and initial iron...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Endocytosis
• Share to Exocytosis
• Share to Hemoglobins