Article
[Significance of neuronal acetylcholine receptors as differentiation antigens in neuroblastomas and paragangliomas].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1990
Marx A, Geuder K I, Altmannsberger M, Schömig E, Kirchner T, Müller-Hermelink H K
Abstract excerpt
Using a panel of monoclonal antibodies to various epitopes of the alpha-, beta- and gamma-subunit of the muscle acetylcholine receptor (AchR), two different immunohistochemical reactivity patterns--corresponding to different neuronal AchRs--were identified in ganglia of the peripheral and central nervous system. The immunoreactivity pattern of neuroblastomas and paragangliomas was identical to the pattern found...
Topics
- Antibodies, Monoclonal
- Antigens, Differentiation
- Ganglia
- Humans
- Immunohistochemistry
- Neuroblastoma
- Neurons
- Paraganglioma
- Phenotype
- Receptors, Cholinergic