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Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes.

Diabetes care - 1 Nov 2006

Yamasaki Yoshimitsu, Katakami Naoto, Sakamoto Ken'ya, Kaneto Hideaki, Matsuhisa Munehide, Sato Hiroshi, Hori Masatsugu, Haneda Masakazu, Kashiwagi Atsunori, Tanaka Yasushi, Kawamori Ryuzo, Kuno Shin-Ichi

Abstract excerpt

OBJECTIVE: Several genetic risk factors, such as single nucleotide polymorphisms (SNPs), in candidate genes have been reported to be responsible for intima-media thickness (IMT), which is one of the surrogate end points of cardiovascular events. However, the synergistic effects of SNPs have not been evaluated in detail. RESEARCH DESIGN AND METHODS: We measured the average IMT of the common and internal carotid...

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PMID: 17065682
DOI: 10.2337/dc06-0871

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LTA
ACE

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