Article
Allele-specific polymerase chain reaction for the imatinib-resistant KIT D816V and D816F mutations in mastocytosis and acute myelogenous leukemia.
The Journal of molecular diagnostics : JMD - 1 Nov 2006
Corless Christopher L, Harrell Patina, Lacouture Mario, Bainbridge Troy, Le Claudia, Gatter Ken, White Clifton, Granter Scott, Heinrich Michael C
Abstract excerpt
Oncogenic mutations of the receptor tyrosine kinase KIT contribute to the pathogenesis of gastrointestinal stromal tumors, systemic mastocytosis (SM), and some cases of acute myelogenous leukemia (AML). The D816V substitution in the activation loop of KIT results in relative resistance to the kinase inhibitor imatinib (Gleevec). Because this mutation occurs in 80 to 95% of adult SM, its detection has diagnostic...
Topics
- Adult
- Aged
- Alleles
- Animals
- Benzamides
- Cell Line
- Female
- Genes, ras
- Humans
- Imatinib Mesylate
- Leukemia, Myeloid, Acute
- Male
- Mastocytosis
- Mice