Article
HIC gene, a candidate suppressor gene within a minimal region of loss at 7q31.1 in myeloid neoplasms.
Leukemia research - 1 Apr 2007
Cigognini Daniela, Corneo Gianmarco, Fermo Elisa, Zanella Alberto, Tripputi Pasquale
Abstract excerpt
We studied monosomy and deletions of chromosome 7 in 170 patients with myeloid disorders and we identified a minimal region of loss in 7q31.1 spanning between the D7S2554 and D7S2460 markers. The closest gene to our most deleted microsatellite, D7S2554, is the human I-mfa domain containing (HIC) gene, alias MyoD family inhibitor domain containing (MDFIC). We investigated the involvement of HIC in myeloid...
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