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Article

Point mutation in meningococcal por A gene associated with increased endemic disease.

Lancet (London, England) - 2 Mar 1991

McGuinness B T, Clarke I N, Lambden P R, Barlow A K, Poolman J T, Jones D M, Heckels J E

Abstract excerpt

The por A gene, which encodes expression of meningococcal class 1 outer membrane protein, responsible for antigenic subtype specificity, has been cloned and sequenced in an isolate of Neisseria meningitidis (B:15:P1.7,16) from a patient in the Gloucester area with meningococcal meningitis. Comparison of the sequence with that of the equivalent gene from the P1.7,16 reference strain reveals a point mutation which...

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Identifiers

PMID: 1705642
DOI: 10.1016/0140-6736(91)91297-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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