A Live Experimental Vaccine against<i>Burkholderia pseudomallei</i>Elicits CD4⁺T Cell–Mediated Immunity, Priming T Cells Specific for 2 Type III Secretion System Proteins

Abstract excerpt

Burkholderia pseudomallei is the etiological agent of melioidosis, a serious human disease for which no vaccine is available. Immunization of susceptible BALB/c mice with the live attenuated mutant B. pseudomallei ilvI (referred to as "2D2") generated significant, although incomplete, immunity. Splenic B. pseudomallei-specific T cells, detected in immunized mice, proliferated and produced interferon-gamma in...

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