Article
The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor.
Blood - 15 Feb 2007
Ghinassi Barbara, Sanchez Massimo, Martelli Fabrizio, Amabile Giovanni, Vannucchi Alessandro Maria, Migliaccio Giovanni, Orkin Stuart H, Migliaccio Anna Rita
Abstract excerpt
Recent evidence suggests that mutations in the Gata1 gene may alter the proliferation/differentiation potential of hemopoietic progenitors. By single-cell cloning and sequential replating experiments of prospectively isolated progenitor cells, we demonstrate here that the hypomorphic Gata1low mut...
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