Update on evidence for a genetic predisposition to cerebral vasospasm.

doi:10.3171/foc.2006.21.3.3

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Article

Update on evidence for a genetic predisposition to cerebral vasospasm.

Neurosurgical focus - 15 Sept 2006

Khurana Vini G, Fox Douglas J, Meissner Irene, Meyer Fredric B, Spetzler Robert F

Abstract excerpt

Considerable evidence links cerebral vasospasm to the decreased bioavailability of endothelial nitric oxide synthase (eNOS) after aneurysmal subarachnoid hemorrhage (SAH). In recent studies from the cardiology literature, researchers have suggested that a genetic predisposition to coronary vasospasm might develop as the result of a T-786C single nucleotide polymorphism (SNP) in the eNOS gene. The authors of this...

Topics

Animals
Apolipoproteins E
Genetic Predisposition to Disease
Haptoglobins
Humans
Models, Biological
Nitric Oxide Synthase Type III
Polymorphism, Single Nucleotide
Vasospasm, Intracranial

Source

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Identifiers

PMID: 17029342
DOI: 10.3171/foc.2006.21.3.3

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