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Article

Transgenic mice can express mutant human coagulation factor IX with higher level of clotting activity.

Biochemical genetics - 1 Oct 2006

Yan Jing-Bin, Wang Shu, Huang Wen-Ying, Xiao Yan-Ping, Ren Zhao-Rui, Huang Shu-Zheng, Zeng Yi-Tao

Abstract excerpt

To improve the available values of transgenic animals, we produced a mutant human coagulation factor IX minigene (including cDNA and intron I) with arginine at 338 changed to alanine (R338A-hFIX) by using a direct mutation technique. The R338A-hFIX minigene was then cloned into a plasmid carrying...

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PMID: 17028784
DOI: 10.1007/s10528-006-9034-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17028784-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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