Article
Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV.
Virology - 20 Feb 2007
Rivera-Amill Vanessa, Noel Richard J, Orsini Suheydi, Tirado Griselle, García José M, Buch Shilpa, Kumar Anil
Abstract excerpt
We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns--fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three...
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