Article
Alpha 1-antitrypsin mutations in NAFLD: high prevalence and association with altered iron metabolism but not with liver damage.
Hepatology (Baltimore, Md.) - 1 Oct 2006
Valenti Luca, Dongiovanni Paola, Piperno Alberto, Fracanzani Anna Ludovica, Maggioni Marco, Rametta Raffaela, Loria Paola, Casiraghi Maria Antonietta, Suigo Elda, Ceriani Roberto, Remondini Erica, Trombini Paola, Fargion Silvia
Abstract excerpt
Hyperferritinemia, a common feature of nonalcoholic fatty liver disease (NAFLD), has been associated with steatohepatitis and fibrosis. Heterozygosity for alpha 1-antitrypsin (AAT) mutations is a cofactor of liver damage, and AAT influences inflammation and iron metabolism. This study evaluated the prevalence of the common AAT PiS/PiZ mutants in 353 patients with NAFLD, 195 of whom had hyperferritinemia, versus...
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