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Article

Soluble and insoluble signals and the induction of bone formation: molecular therapeutics recapitulating development

27 Sept 2006

Abstract excerpt

The osteogenic molecular signals of the transforming growth factor-beta (TGF-beta) superfamily, the bone morphogenetic/osteogenic proteins (BMPs/OPs) and uniquely in primates the TGF-beta isoforms per se, pleiotropic members of the TGF-beta supergene family, induce de novo endochondral bone formation as a recapitulation of embryonic development. Naturally derived BMPs/OPs and gamma-irradiated human recombinant...

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Identifiers

PMID: 17005018
DOI: 10.1111/j.1469-7580.2006.00635.x

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