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Article

A silent mutation (2939G>A, exon 6; CYP2D6*59) leading to impaired expression and function of CYP2D6.

Pharmacogenetics and genomics - 1 Oct 2006

Toscano Claudia, Raimundo Sebastian, Klein Kathrin, Eichelbaum Michel, Schwab Matthias, Zanger Ulrich M

Abstract excerpt

We analyzed CYP2D6 in two individuals characterized by impaired sparteine oxidation (intermediate metabolizer phenotype) and genotype 2D62/4 (1661G>C; 2850C>T; 4180G>C) usually associated with normal function. Full genomic sequencing and haplotype analysis confirmed the previously identified silent mutation 2939G>A in exon 6 (former allele variant 2D62J, now termed 2D659), as well as an additional novel 2291G>A...

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PMID: 17001296
DOI: 10.1097/01.fpc.0000236331.03681.24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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