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Article

Characterization of recombinant factor VIII and a recombinant factor VIII deletion mutant using a rabbit immunogenicity model system.

Blood - 15 Oct 1990

Esmon P C, Kuo H S, Fournel M A

Abstract excerpt

The use of factor VIII prepared genetically engineered cell lines (rFVIII) may avoid some of the problems inherently associated with administering plasma-derived factor VIII (pdFVIII) concentrates to hemophilia A patients. Although rFVIII may represent an improvement over traditional therapeutics, the chance exists that protein production in cell culture may result in the presence of novel epitopes that may...

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Identifiers

PMID: 1698481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Characterization of recombinant factor VIII and a recombinant factor VIII deletion mutant using a rabbit immunogenicity model system.PMID 1698481Read ↗

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A Deletion Variant of Human Factor VIII Displaying Low Immunogenicity in a Murine Model of Hemophilia ASemantic proximity Read ↗

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Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools.Semantic proximity Read ↗

Role of coagulation-associated processes on factor VIII immunogenicity in a mouse model of severe hemophilia A.Semantic proximity Read ↗

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