Fibrin gel improved the spatial uniformity and phenotype of human chondrocytes seeded on collagen scaffolds.

doi:10.1002/bit.21038

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Article

Fibrin gel improved the spatial uniformity and phenotype of human chondrocytes seeded on collagen scaffolds.

Biotechnology and bioengineering - 1 Feb 2007

Malicev Elvira, Radosavljevic Damjan, Velikonja Nevenka Kregar

Abstract excerpt

A scaffold made of equine collagen type I based material has been assessed for its use in the preparation of tissue-engineered cartilage implants with human articular chondrocytes. Improvements of cell-seeding efficiency and specific gene expression were studied by combining solid scaffold with fibrin glue or human blood plasma. Following 3 weeks of static culture, mRNA expression levels of collagen type I,...

Topics

Adult
Cell Differentiation
Cells, Cultured
Chondrocytes
Collagen
Fibrin Tissue Adhesive
Humans
Male
Phenotype
RNA
Reverse Transcriptase Polymerase Chain Reaction
Surface Properties
Tissue Engineering

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Open in PubMed

Identifiers

PMID: 16981186
DOI: 10.1002/bit.21038

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