Lymphocyte functional antigens stabilize agglutination between Reed-Sternberg cells and T cells, but are not responsible for homotypic binding of Hodgkin's Reed-Sternberg cells.

Article

Lymphocyte functional antigens stabilize agglutination between Reed-Sternberg cells and T cells, but are not responsible for homotypic binding of Hodgkin's Reed-Sternberg cells.

The American journal of pathology - 1 Sept 1990

Hsu S M, Hsu P L

Abstract excerpt

The neoplastic (Hodgkin's Reed-Sternberg [H-RS]) cells in Hodgkin's disease (HD) are known for their unique capacity to form rosettes with unprimed T cells. Recently, a family of leukocyte-adherence molecules (LFA-1 and LFA-2) has been identified on T lymphocytes. The molecules bind to intercellular-adhesion molecules (ICAMs) and to LFA-3, respectively, which are associated with antigen-presenting cells. In this...

Topics

Adult
Aged
Agglutination
Antibodies, Monoclonal
Antigens, Surface
CD58 Antigens
Cell Adhesion Molecules
Hodgkin Disease
Humans
Immunoenzyme Techniques
Intercellular Adhesion Molecule-1

Male

Membrane Glycoproteins

Phenotype

T-Lymphocytes

Tumor Cells, Cultured

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