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Article

Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections.

Parasitology - 1 Dec 2006

Long G H, Chan B H K, Allen J E, Read A F, Graham A L

Abstract excerpt

The pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha) is associated with malaria virulence (disease severity) in both rodents and humans. We are interested in whether parasite genetic diversity influences TNF-mediated effects on malaria virulence. Here, primary infections with genetically distinct Plasmodium chabaudi chabaudi (P.c.c.) clones varied in the virulence and cytokine responses induced...

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Identifiers

PMID: 16978451
DOI: 10.1017/S003118200600117X

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TNF

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