Article
Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections.
Proceedings. Biological sciences - 22 May 2004
de Roode Jacobus C, Culleton Richard, Cheesman Sandra J, Carter Richard, Read Andrew F
Abstract excerpt
During an infection, malaria parasites compete for limited amounts of food and enemy-free space. Competition affects parasite growth rate, transmission and virulence, and is thus important for parasite evolution. Much evolutionary theory assumes that virulent clones outgrow avirulent ones, favouring the evolution of higher virulence. We infected laboratory mice with a mixture of two Plasmodium chabaudi clones:...
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