Dynamic increase of a 45,X cell line in a patient with multicentric ring Y chromosomes.

doi:10.1159/000094805

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Article

Dynamic increase of a 45,X cell line in a patient with multicentric ring Y chromosomes.

Cytogenetic and genome research - 1 Jan 2006

DesGroseilliers M, Fortin F, Lafrenière A-M, Brochu P, Lemyre E, Lemieux N

Abstract excerpt

Because ring Y chromosomes are unstable during cell division most reported patients are mosaics, usually including a 45,X cell line. The phenotype varies from normal males or females with streak gonads to sexual ambiguities. We present here the case of a 23-year-old man who was referred at 11 years for growth delay. The GTG-banded karyotypes of lymphocytes revealed two cell lines: 46,X,dic r(Y) seen in 76% of the...

Topics

Adult
Cell Lineage
Chromosome Aberrations
Chromosomes, Human, X
Chromosomes, Human, Y
Genetic Diseases, Y-Linked
Growth Disorders
Humans
Male
Mosaicism
Phenotype

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Open in PubMed

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PMID: 16974088
DOI: 10.1159/000094805

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