Article
Declining prevalence of HIV-1 drug resistance in antiretroviral treatment-exposed individuals in Western Europe.
The Journal of infectious diseases - 15 Apr 2013
De Luca Andrea, Dunn David, Zazzi Maurizio, Camacho Ricardo, Torti Carlo, Fanti Iuri, Kaiser Rolf, Sönnerborg Anders, Codoñer Francisco M, Van Laethem Kristel, Vandamme Anne-Mieke, Bansi Loveleen, Ghisetti Valeria, van de Vijver David A M C, Asboe David, Prosperi Mattia C F, Di Giambenedetto Simona
Abstract excerpt
HIV-1 drug resistance represents a major obstacle to infection and disease control. This retrospective study analyzes trends and determinants of resistance in antiretroviral treatment (ART)-exposed individuals across 7 countries in Europe. Of 20 323 cases, 80% carried at least one resistance mutation: these declined from 81% in 1997 to 71% in 2008. Predicted extensive 3-class resistance was rare (3.2% considering...
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