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Article

Topoisomerase II beta expression level correlates with doxorubicin-induced apoptosis in peripheral blood cells.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Oct 2006

Kersting Gisela, Tzvetkov Mladen V, Huse Klaus, Kulle Bettina, Hafner Verena, Brockmöller Jürgen, Wojnowski Leszek

Abstract excerpt

Anthracyclines are widely used in oncology. Both the response and side-effects of anthracyclines are individually variable, but determinants or predictive markers of this variability are not available. We investigated the variability in the expression of the anthracycline targets topoisomerases II (topo II) alpha and beta and its significance for the apoptotic response following exposure to the anthracycline...

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Source

Identifiers

PMID: 16957942
DOI: 10.1007/s00210-006-0091-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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