Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease: implications for neuronal loss in Gaucher disease

1 Aug 2006

Abstract excerpt

Gaucher disease is a glycosphingolipid storage disease caused by deficiency of glucocerebrosidase, resulting in the accumulation of glucosylceramide in lysosomes. The neuronopathic forms of this disease are associated with neuronal loss and neurodegeneration. However, the pathophysiological mechanisms leading to prenatal and neonatal death remain uncharacterized. To investigate brain dysfunction in Gaucher...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Lysosomal Storage Disorders Research
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16953113
DOI: 10.1038/emm.2006.41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease: implications for neuronal loss in Gaucher diseasePMID 16953113Read ↗

Murine models of acute neuronopathic Gaucher diseaseSemantic proximity Read ↗

Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidosesSemantic proximity Read ↗

Brain pathology and cerebellar purkinje cell loss in a mouse model of chronic neuronopathic Gaucher diseaseSemantic proximity Read ↗

Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease.Semantic proximity Read ↗

Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.Semantic proximity Read ↗

Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels.Semantic proximity Read ↗

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.Semantic proximity Read ↗

Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro.Semantic proximity Read ↗

Attenuated plasticity in neurons and astrocytes in the mouse model of Sanfilippo syndrome type BSemantic proximity Read ↗

Progranulin is expressed within motor neurons and promotes neuronal cell survivalSemantic proximity Read ↗

Abnormalities in the cerebellar levels of trophic factors BDNF and GDNF in pcd and lurcher cerebellar mutant mice.Semantic proximity Read ↗

Restoring neuronal progranulin reverses deficits in a mouse model of frontotemporal dementiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.