Article
Common alpha-thalassemia deletions in transfusion-dependent thalassemia patients in the Southeast Asia region of Myanmar.
Laboratory hematology : official publication of the International Society for Laboratory Hematology - 1 Jan 2006
Ne-Win, Harano Keiko, Harano Teruo, Thein-Thein-Myint, Rai-Mra, Aye-Aye-Myint, Shimono Kunio, Okada Shigeru
Abstract excerpt
Screening of 3 common alpha-thalassemia (thal) deletions (-alpha3.7, -alpha4.2 and --SEA) in Southeast Asia was done by polymerase chain reaction in 170 unrelated Myanmar thal patients receiving transfusions. Thal deletions were detected in 27 patients (15.9%) as: (1) alpha-thal-2 (-alpha3.7/alphaalpha) in 12 heterozygous or hemoglobin (Hb) E-beta-thal cases; (2) alpha-thal-1 in 7 patients (2-alpha3.7/-alpha3.7...
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