Article
Mutations of connexin 26 at position 75 and dominant deafness: essential role of arginine for the generation of functional gap-junctional channels.
Hearing research - 1 Oct 2006
Deng Yanqin, Chen Yongyue, Reuss Luis, Altenberg Guillermo A
Abstract excerpt
Gap-junctional channels are large intercellular aqueous pores formed by head-to-head association of two gap-junctional hemichannels (connexin hexamers), one from each of the adjacent cells. The mechano-transduction of sound waves into electrical impulses occurs in the cochlea, which houses the organ of Corti. Hereditary deafness is frequent and mutations of connexin 26, the predominant connexin of the cochlea,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.