Article
Matrix metalloproteinase-1 gene polymorphism in renal transplant patients with and without gingival enlargement.
Journal of periodontology - 1 Sept 2006
Kurzawski Mateusz, Drozdzik Agnieszka, Dembowska Ewa, Pawlik Andrzej, Banach Jadwiga, Drozdzik Marek
Abstract excerpt
BACKGROUND: Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporin use results in a disturbance of the homeostatic balance, which is characterized by an increase in the number of fibroblasts and volume of the extracellular matrix. Matrix metalloproteinase (MMP) serves as an initiator of...
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