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Article

SPARC gene polymorphism in renal transplant patients with gingival overgrowth.

Journal of periodontology - 1 Nov 2007

Drozdzik A, Kurzawski M, Kozak M, Banach J, Drozdzik M

Abstract excerpt

BACKGROUND: Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporin use results from increases in the number of fibroblasts and the volume of extracellular matrix. SPARC (secreted protein, acidic, and rich in cysteine) regulates cell-matrix interactions, binding to structural matrix proteins, and is...

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Source

Identifiers

PMID: 17970686
DOI: 10.1902/jop.2007.070115

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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