Article
Interaction between FtsW and penicillin-binding protein 3 (PBP3) directs PBP3 to mid-cell, controls cell septation and mediates the formation of a trimeric complex involving FtsZ, FtsW and PBP3 in mycobacteria.
Molecular microbiology - 1 Dec 2006
Datta Pratik, Dasgupta Arunava, Singh Anil Kumar, Mukherjee Partha, Kundu Manikuntala, Basu Joyoti
Abstract excerpt
In bacteria, biogenesis of cell wall at the division site requires penicillin-binding protein 3 (PBP3) (or Ftsl). Using pull-down, bacterial two-hybrid, and peptide-based interaction assays, we provide evidence that FtsW of Mycobacterium tuberculosis (FtsWMTB) interacts with PBP3 through two extr...
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