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Article

Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity.

Journal of medicinal chemistry - 7 Sept 2006

Pratt David J, Bentley Jo, Jewsbury Philip, Boyle F Tom, Endicott Jane A, Noble Martin E M

Abstract excerpt

Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four residues of the cyclin-dependent kinase active site in inhibitor selectivity were investigated by producing cyclin-dependent kinase 2 muta...

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Identifiers

PMID: 16942020
DOI: 10.1021/jm060216x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16942020-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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