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Article

Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis.

Human mutation - 1 Oct 2006

Lejeune Sophie, Guillemot François, Triboulet Jean-Pierre, Cattan Stéphane, Mouton Christine, Porchet Nicole, Manouvrier Sylvie, Buisine Marie-Pierre

Abstract excerpt

Familial adenomatous polyposis has been linked to germline mutations in the APC tumor suppressor gene. However, a number of patients with familial adenomatous polyposis (with either classical or attenuated phenotype) have no APC mutation. Recently, germline mutations in the Wnt pathway component gene AXIN2 have been associated with tooth agenesis-colorectal cancer syndrome. Moreover, biallelic mutations in the...

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Share to Adenomatous Polyposis Coli
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16941501
DOI: 10.1002/humu.9460

Genes

MUTYH
AXIN2
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Low frequency of AXIN2 mutations and high frequency of MUTYH mutations in patients with multiple polyposis.PMID 16941501Read ↗

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