Article
Phenotypic abnormalities observed in aged cloned mice from embryonic stem cells after long-term maintenance.
Reproduction (Cambridge, England) - 1 Sept 2006
Shimozawa Nobuhiro, Sotomaru Yusuke, Eguchi Natsuko, Suzuki Shuzo, Hioki Kyoji, Usui Toshimi, Kono Tomohiro, Ito Mamoru
Abstract excerpt
Somatic/embryonic stem cell cloning has made it possible to produce an individual genomically identical to another individual. However, the cloned animals have a variety of abnormalities caused by the aberrant gene modification, with insufficient reprogramming in cloning. We previously reported abnormalities in cloned mice at birth. In this study, we examined what abnormalities could be seen in cloned mice after...
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