Article
Childhood cancer in families with and without BRCA1 or BRCA2 mutations ascertained at a high-risk breast cancer clinic.
Cancer biology & therapy - 1 Sept 2006
Brooks Gabriel A, Stopfer Jill E, Erlichman Julie, Davidson Rebecca, Nathanson Katherine L, Domchek Susan M
Abstract excerpt
BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes are associated with breast cancer, ovarian cancer and other malignancies. Biallelic mutations of BRCA2 are a cause of Fanconi anemia and characteristic childhood cancers. We undertook this study to evaluate the contribution of familial BRCA mutations to childhood cancer in hereditary breast cancer families. PATIENTS AND METHODS: We compared the...
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