Article
Effect of cotreatment of aspirin metabolites on mitomycin C-induced genotoxicity using the somatic mutation and recombination test in Drosophila melanogaster.
Drug and chemical toxicology - 1 Jan 2006
Niikawa Miki, Nakamura Takeshi, Nagase Hisamitsu
Abstract excerpt
In our previous reports, aspirin, an antipyretic analgesic, suppressed the genotoxicity of mitomycin C (MMC) in a somatic mutation and recombination test (SMART) in Drosophila melanogaster. In order to reveal the mechanism of the anti-genotoxicity of aspirin, we evaluated the suppressing ability of each aspirin metabolite, such as salicylic acid (SA), salicyluric acid (SUA), gentisic acid (GA), gentisuric acid...
Topics
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Antimutagenic Agents
- Aspirin
- Dose-Response Relationship, Drug
- Drosophila melanogaster
- Drug Antagonism
- Drug Therapy, Combination
- Female
- Male
- Mitomycin
- Mutagens
- Mutation
- Recombination, Genetic