Article
Optimization of the Y831C mutation detection in human DNA polymerase gamma by allelic discrimination assay.
Acta biochimica Polonica - 1 Jan 2006
Stopińska Katarzyna, Grzybowski Tomasz, Malyarchuk Boris A, Derenko Miroslava V, Miścicka-Sliwka Danuta
Abstract excerpt
Many well-defined mutations in the gene for the catalytic subunit of polymerase gamma (POLG1) have been found to be associated with disease, whereas the status of several mutations remains unresolved due to the conflicting reports on their frequencies in populations of healthy individuals. Here, we have developed a highly sensitive, real-time allelic discrimination assay enabling detection of the Y831C mutation...
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