Article
Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006
Alnaeeli Mawadda, Penninger Josef M, Teng Yen-Tung Andy
Abstract excerpt
Dendritic cells (DC) are innate immune effectors and are critically involved in regulating T cell immunity. Osteoclasts (OC) are bone-resorbing cells derived from the monocyte/macrophage lineage in response to receptor activator of NF-kappaB ligand (RANKL). DC and T cells form aggregates in the i...
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