Article
Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006
Donati Daria, Mok Bobo, Chêne Arnaud, Xu Hong, Thangarajh Mathula, Glas Rickard, Chen Qijun, Wahlgren Mats, Bejarano Maria Teresa
Abstract excerpt
Chronic malaria infection is characterized by polyclonal B cell activation, hyperglobulinemia, and elevated titers of autoantibodies. We have recently identified the cysteine-rich interdomain region 1alpha (CIDR1alpha) of the Plasmodium falciparum erythrocyte membrane protein 1 as a T cell-independent polyclonal B cell activator and Ig binding protein. Here, we show that, although the binding affinity of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.