Article
[The genetic activity of NO-containing agents is regulated by complex formation with intracellular iron].
Genetika - 1 Jul 2006
Vasil'eva S V, Moshkovskaia E Iu, Terekhov A S, Sanina N A, Aldoshin S M
Abstract excerpt
This work is a part of a directional search for new crystal donors of nitric oxide (NO), which are promising for complex chemotherapy. The relationships between the physico-chemical properties of NO donors, their genotoxic and mutagenic activities, and the dependence on intracellular iron were studied. New crystal NO donors (di- and trinitrosyl iron complexes with synthetic ligands) were examined for the first...
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