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Article

Ubiquitylation-independent ER-associated degradation of an AE1 mutant associated with dominant hereditary spherocytosis in cattle.

Journal of cell science - 1 Sept 2006

Ito Daisuke, Koshino Ichiro, Arashiki Nobuto, Adachi Hirokazu, Tomihari Mizuki, Tamahara Satoshi, Kurogi Kazuhito, Amano Takashi, Ono Ken-ichiro, Inaba Mutsumi

Abstract excerpt

Various mutations in the AE1 (anion exchanger 1, band 3) gene cause dominant hereditary spherocytosis, a common congenital hemolytic anemia associated with deficiencies of AE1 of different degrees and loss of mutant protein from red blood cell membranes. To determine the mechanisms underlying decreases in AE1 protein levels, we employed K562 and HEK293 cell lines and Xenopus oocytes together with bovine wild-type...

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Identifiers

PMID: 16912075
DOI: 10.1242/jcs.03101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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