Article
T-cell prolymphocytic leukemia: an aggressive T cell malignancy with frequent cutaneous tropism.
Journal of the American Academy of Dermatology - 1 Sept 2006
Magro Cynthia M, Morrison Carl D, Heerema Nyla, Porcu Pierluigi, Sroa Novie, Deng April C
Abstract excerpt
BACKGROUND: T-cell prolymphocytic leukemia (T-PLL), formerly categorized as T-cell chronic lymphocytic leukemia, is a rare and aggressive hematologic malignancy. Although the skin is characteristically involved, it is not a well-recognized entity in the dermatologic literature. METHODS: Six cases of cutaneous T-PLL are presented from a clinical, light microscopic, and phenotypic perspective. RESULTS: The patient...
Topics
- Aged
- Aged, 80 and over
- Aneuploidy
- Antigens, CD
- Antigens, Neoplasm
- CD4-Positive T-Lymphocytes
- CD52 Antigen
- CD8-Positive T-Lymphocytes
- Cytogenetic Analysis
- Face
- Female
- Gene Amplification
- Gene Rearrangement