Evolution of linkage disequilibrium of the founders in exponentially growing populations.

Abstract excerpt

Evolution of linkage disequilibrium of the founders in exponentially growing populations was studied using a time-inhomogeneous Itô process model. The model is an extension of the diffusion approximation of the Wright-Fisher model. As a measure of linkage disequilibrium, the squared standard linkage deviation, which is defined by a ratio of the moments, was considered. A system of ordinary differential equations...

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