Article
Genotyping of different varicella vaccine strains.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Oct 2006
Sauerbrei A, Zell R, Harder M, Wutzler P
Abstract excerpt
BACKGROUND: Little is known about single nucleotide polymorphism (SNP) in different lots of varicella vaccines distributed by the manufacturers. Recently, the genetic analysis of several genomic regions revealed a polymorphism in different vaccine lots of Varilrix manufactured by GlaxoSmithKline. These findings need attention since mutations in the vaccine strain could result in changes of virulence and efficacy...
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