Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations.

Neurology - 8 Aug 2006

Sicotte N L, Salamon G, Shattuck D W, Hageman N, Rüb U, Salamon N, Drain A E, Demer J L, Engle E C, Alger J R, Baloh R W, Deller T, Jen J C

Abstract excerpt

Horizontal gaze palsy with progressive scoliosis (HGPPS) is caused by mutations in the ROBO3 gene, critical for the crossing of long ascending medial lemniscal and descending corticospinal tracts in the medulla. Diffusion tensor imaging in a patient with HGGPS revealed the absence of major pontin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Diseases
Share to Brain Stem
Share to Diffusion Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Family Health

Share to Receptors, Cell Surface

Share to Receptors, Immunologic

Share to Scoliosis

Source

Identifiers

PMID: 16894121
DOI: 10.1212/01.wnl.0000227960.38262.0c

Genes

ROBO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16894121-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Diffusion tensor MRI shows abnormal brainstem crossing fibers associated with ROBO3 mutations.PMID 16894121Read ↗

Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3.Semantic proximity Read ↗

Horizontal gaze palsy with progressive scoliosis: Further expanding the ROBO3 spectrum.Semantic proximity Read ↗

Early-onset or rapidly progressive scoliosis in children: check the eyes!Semantic proximity Read ↗

Allelic ROBO3 heterogeneity in Tunisian patients with horizontal gaze palsy with progressive scoliosis.Semantic proximity Read ↗

Compound Heterozygous Variants in ROBO1 Cause a Neurodevelopmental Disorder With Absence of Transverse Pontine Fibers and Thinning of the Anterior Commissure and Corpus Callosum.Semantic proximity Read ↗

Patients with horizontal gaze palsy and progressive scoliosis due to ROBO3 E319K mutation have both uncrossed and crossed central nervous system pathways and perform normally on neuropsychological testing.Semantic proximity Read ↗

Five new consanguineous families with horizontal gaze palsy and progressive scoliosis and novel ROBO3 mutations.Semantic proximity Read ↗

Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.Semantic proximity Read ↗

Horizontal gaze palsy with progressive scoliosis (HGPPS): expanding ROBO3 molecular spectrum and refining clinical-neuroimaging phenotypes.Semantic proximity Read ↗

Ipsilateral stroke in a patient with horizontal gaze palsy with progressive scoliosis and a subcortical infarct.Semantic proximity Read ↗

Teaching NeuroImage: ROBO3 Mutation Causing Horizontal Gaze Palsy and Brainstem Malformation.Semantic proximity Read ↗

Horizontal gaze palsy with progressive scoliosis: three novel ROBO3 mutations and descriptions of the phenotypes of four patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.