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Article

The acid-induced operon Rv3083-Rv3089 is required for growth of Mycobacterium tuberculosis in macrophages.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2007

Cheruvu Mani, Plikaytis Bonnie B, Shinnick Thomas M

Abstract excerpt

The Rv3083-Rv3089 operon of Mycobacterium tuberculosis has been shown to be induced 17-33-fold when tubercle bacilli were exposed in vitro to acidic conditions which may mimic those that the bacilli encounter early during the infection and it is induced during growth in macrophages. To understand the role of this operon in intracellular survival, we constructed a knockout of the operon in the M. tuberculosis...

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Identifiers

PMID: 16893682
DOI: 10.1016/j.tube.2006.01.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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