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Article

Structure-based analysis of the beta8 interactive sequence of human alphaB crystallin.

Biochemistry - 15 Aug 2006

Ghosh Joy G, Estrada Marcus R, Clark John I

Abstract excerpt

The functional importance of the beta8 sequence ((131)LTITSSLS(138)), which is on the surface of the alpha crystallin core domain of human alphaB crystallin, was evaluated using site-directed mutagenesis. Ultraviolet circular dichroism determined that mutating the surface-exposed, nonconserved residues, Leu-131, Thr-132, Thr-134, Ser-135, Ser-136, and Ser-138 individually or in combination (alphaAbeta8 and...

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Share to alpha-Crystallin B Chain
Share to Chromatography, Gel
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16893188
DOI: 10.1021/bi060970k

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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