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Article

Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins.

The Journal of biological chemistry - 13 Oct 2006

Bouchard Rodolphe, Bailly Aurélien, Blakeslee Joshua J, Oehring Sophie C, Vincenzetti Vincent, Lee Ok Ran, Paponov Ivan, Palme Klaus, Mancuso Stefano, Murphy Angus S, Schulz Burkhard, Geisler Markus

Abstract excerpt

The immunophilin-like protein TWISTED DWARF1 (TWD1/FKBP42) has been shown to physically interact with the multidrug resistance/P-glycoprotein (PGP) ATP-binding cassette transporters PGP1 and PGP19 (MDR1). Overlapping phenotypes of pgp1/pgp19 and twd1 mutant plants suggested a positive regulatory role of TWD1 in PGP-mediated export of the plant hormone auxin, which controls plant development. Here, we provide...

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PMID: 16887800
DOI: 10.1074/jbc.M604604200

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PGP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Immunophilin-like TWISTED DWARF1 modulates auxin efflux activities of Arabidopsis P-glycoproteins.PMID 16887800Read ↗

The ER-localized TWD1 immunophilin is necessary for localization of multidrug resistance-like proteins required for polar auxin transport in Arabidopsis roots.Semantic proximity Read ↗

TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19.Semantic proximity Read ↗

Arabidopsis TWISTED DWARF1 functionally interacts with auxin exporter ABCB1 on the root plasma membrane.Semantic proximity Read ↗

Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1.Semantic proximity Read ↗

Expression of TWISTED DWARF1 lacking its in-plane membrane anchor leads to increased cell elongation and hypermorphic growth.Semantic proximity Read ↗

Interactions among PIN-FORMED and P-glycoprotein auxin transporters in Arabidopsis.Semantic proximity Read ↗

TWISTED DWARF 1 Associates with BRASSINOSTEROID-INSENSITIVE 1 to Regulate Early Events of the Brassinosteroid Signaling Pathway.Semantic proximity Read ↗

A conserved D/E-P motif in the nucleotide binding domain of plant ABCB/PGP-type ABC transporters defines their auxin transport capacitySemantic proximity Read ↗

Sterols and sphingolipids differentially function in trafficking of the Arabidopsis ABCB19 auxin transporter.Semantic proximity Read ↗

PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in Arabidopsis thaliana roots.Semantic proximity Read ↗

Overexpression of auxin-binding protein enhances the sensitivity of guard cells to auxin.Semantic proximity Read ↗

Arabidopsis Flippases Cooperate with ARF GTPase Exchange Factors to Regulate the Trafficking and Polarity of PIN Auxin Transporters.Semantic proximity Read ↗

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