Article
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
The New England journal of medicine - 3 Aug 2006
Pearson Ewan R, Flechtner Isabelle, Njølstad Pål R, Malecki Maciej T, Flanagan Sarah E, Larkin Brian, Ashcroft Frances M, Klimes Iwar, Codner Ethel, Iotova Violeta, Slingerland Annabelle S, Shield Julian, Robert Jean-Jacques, Holst Jens J, Clark Penny M, Ellard Sian, Søvik Oddmund, Polak Michel, Hattersley Andrew T
Abstract excerpt
BACKGROUND: Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (K(ATP)) channel, cause 30 to 58 percent of cases of diabetes diagnosed in patients under six months of age. Patients present with ketoacidosis or severe hyperglycemia and are treated with insulin. Diabetes results from impaired insulin secretion caused by a failure of the beta-cell K(ATP) channel...
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